This exploratory qualitative study investigated how doctoral students reported their personal and professional interaction experiences that they believed might facilitate or impede their academic pursuits in biomedical research. We collected 19 in-depth interviews with doctoral students in biomedical research from eight universities, and we based our qualitative analytic approach on the work of Miles and Huberman. The results indicated that among different sources and types of interaction, academic and emotional interactions from family and teachers in various stages essentially affected students’ (...) persistence in the biomedical science field. In addition, co-mentorship among peers, departmental environment, and volunteer experiences were other essential factors. This study also found related experiences among women and underrepresented minority students that were important to their academic pursuit. (shrink)

This paper corrects three widely held misunderstandings about Maxent when used in common sense reasoning: That it is language dependent; That it produces objective facts; That it subsumes, and so is at least as untenable as, the paradox-ridden Principle of Insufficient Reason.

We consider two formalizations of the notion of irrelevance as a rationality principle within the framework of (Carnapian) Inductive Logic: Johnson's Sufficientness Principle, JSP, which is classically important because it leads to Carnap's influential Continuum of Inductive Methods and the recently proposed Weak Irrelevance Principle, WIP. We give a complete characterization of the language invariant probability functions satisfying WIP which generalizes the Nix-Paris Continuum. We argue that the derivation of two very disparate families of inductive methods from alternative perceptions of (...) 'irrelevance' is an indication that this notion is imperfectly understood at present. (shrink)

Rewards are reinforcement mechanisms that organizations use to shape desirable employee behaviors. However, rewards may also have unintended consequences, such as building expectations for receiving extra benefits and weakening employee barriers to unethical acts. This article investigates the dark side of the reward–behavior association, and exploring what is referred to as the reward–theft parity effect (RTPE). The authors hypothesize that receiving rewards induces a corresponding type of theft. In Study 1, survey results (n = 634) show initial support for the (...) RTPE between rewards and same‐category theft, and that perceptions of procedural justice attenuate this association. Study 2 involved a 2 (reward) × 2 (theft opportunity) between‐subjects experimental design (n = 300) and provides further support for the RTPE by revealing greater theft under a reward–theft parity condition than under a reward–theft disparity condition. Study 3 replicates these findings in a field experiment (n = 285) and finds that the RTPE is exacerbated when the reward–behavior task is perceived as unjust. Collectively, these findings provide new theoretical insights while also giving managers a more complete understanding of the dark side of behavioral reinforcement mechanisms. (shrink)

Business Ethics, the Environment &Responsibility, Volume 31, Issue 3, Page 846-858, July 2022.

A necessary and sufficient condition in terms of a de Finetti style representation is given for a probability function in Polyadic Inductive Logic to satisfy being part of a Language Invariant family satisfying Spectrum Exchangeability. This theorem is then considered in relation to the unary Carnap and Nix–Paris Continua.

The Repugnant Conclusion served an important purpose in catalyzing and inspiring the pioneering stage of population ethics research. We believe, however, that the Repugnant Conclusion now receives too much focus. Avoiding the Repugnant Conclusion should no longer be the central goal driving population ethics research, despite its importance to the fundamental accomplishments of the existing literature.

Tests of economic theory often focus on choice outcomes and find significant individual differences in these outcomes. This variability may mask universal psychological processes that lead to different choices because of differences across cultures in the information people have available when making decisions. On this view, decision making research within and across cultures must focus on the processes underlying choice.

Different aspects of people's interactions with money are best conceptualized using the drug and tool theories. The key question is when these models of money are most likely to guide behavior. We suggest that the Drug Theory characterizes motivationally active uses of money and that the Tool Theory characterizes behavior in motivationally cool situations. (Published Online April 5 2006).

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

In this paper, we present three necessary conditions for morally responsible animal research that we believe people on both sides of this debate can accept. Specifically, we argue that, even if human beings have higher moral status than nonhuman animals, animal research is morally permissible only if it satisfies (a) an expectation of sufficient net benefit, (b) a worthwhile-life condition, and (c) a no unnecessary-harm/qualified-basic-needs condition. We then claim that, whether or not these necessary conditions are jointly sufficient conditions of (...) justified animal research, they are relatively demanding with the consequence that many animal experiments may fail to satisfy them. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This is a position paper concerning the role of empirical studies of human default reasoning in the formalization of AI theories of default reasoning. We note that AI motivates its theoretical enterprise by reference to human skill at default reasoning, but that the actual research does not make any use of this sort of information and instead relies on intuitions of individual investigators. We discuss two reasons theorists might not consider human performance relevant to formalizing default reasoning: (a) that intuitions (...) are sufficient to describe a model, and (b) that human performance in this arena is irrelevant to a competence model of the phenomenon. We provide arguments against both these reasons. We then bring forward three further considerations against the use of intuitions in this arena: (a) it leads to an unawareness of predicate ambiguity, (b) it presumes an understanding of ordinary language statements of typicality, and (c) it is similar to discredited views in other fields. We advocate empirical investigation of the range of human phenomena that intuitively embody default reasoning. Gathering such information would provide data with which to generate formal default theories and against which to test the claims of proposed theories. Our position is that such data are the very phenomena that default theories are supposed to explain. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Transitive inference is claimed to be “deductive”. Yet every group/species ever reported apparently uses it. We asked 58 adults to solve five-term transitive tasks, requiring neither training nor premise learning. A computer-based procedure ensured all premises were continually visible. Response accuracy and RT (non-discriminative nRT ) were measured as is typically done. We also measured RT confined to correct responses ( cRT ). Overall, very few typical transitive phenomena emerged. The symbolic distance effect never extended to premise recall and was (...) not at all evident for nRT ; suggesting the use of non-deductive end-anchor strategies. For overall performance, and particularly the critical B ? D inference, our findings indicate that deductive transitive inference is far more intellectually challenging than previously thought. Contrasts of our present findings against previous findings suggest at least two distinct transitive inference modes, with most research and most computational models to date targeting an associative mode rather than their desired deductive mode. This conclusion fits well with the growing number of theories embracing a “dual process” conception of reasoning. Finally, our differing findings for nRT versus cRT suggest that researchers should give closer consideration to matching the RT measure they use to the particular conception of transitive inference they pre-held. (shrink)

This essay makes two points: (a) Dualities between implicit and explicit?like the older ones between body and mind, primary and secondary process, nonverbal and symbolic, inner and outer, unconscious and conscious, emotion and cognition, and so on?can be understood as poles on a complex continuum of experience or as aspects of complex experiential systems; and (b) metaphor in dialogue can create a process of understanding between people and aspects of their experience that seem, on the face of it, to be (...) very far apart or even beyond comprehension. (shrink)

ABSTRACT Many Buddhist teachers in North America teach forgiveness: an attitude of non-anger not conditional on wrongdoers repairing their wrongs. Classical Buddhist texts and premodern Buddhist cultures also taught forgiveness: the act of reconciling after wrongdoers repaired wrongs. This article describes traditional Buddhist forgiveness processes, analyses how new processes to forgive arose in North America, and outlines the current state of Buddhist forgiveness teachings there. It shows that the predominant way North American Buddhists now teach forgiveness is new. It developed (...) in the 1970–1990 period and incorporates non-Buddhist discourses. In addition to clarifying what forgiveness has long been in Buddhism and how, in North America, changes to that occurred, the article notes the frequent absence, among academic scholars and Buddhists alike, of awareness concerning (a) the replacement of longstanding Buddhist teachings on forgiveness by new teachings; (b) the predominantly non-Buddhist sources of the new teachings; and (c) the impact on victims, wrongdoers, relationships, and communities of the new teachings. The article contributes to scholarship on Buddhist ethics, forgiveness in Buddhism, and the development and hybridisation of Buddhism in North America. (shrink)

Robert Pippin helped revolutionize the interpretation of Hegel in the English-speaking world. Reviving and developing the early American pragmatist treatment of Hegel as a philosopher whose metaphy...

Imagine this scenario: a bank customer walks up to an ATM to withdraw cash from her account. While entering her PIN, she accidentally presses the '3' key at the same time as the 'Clear' key. Instantly $100 comes out of the cash dispenser! Curious, she checks the receipt and seeing that the money did not from her account, she tries the same operation. Again, $100 comes out of the cash dispenser. At this point she has two options, A: she can (...) continue to take advantage of this obvious flaw and tell her friends, or B: she can report this problem to the bank, telling no one else. While Kantian ethics might require the latter, the issue becomes much grayer when it comes to computer software vulnerabilities. Many variables exist to cloud the ethical judgment of a software flaw's discoverer. The question becomes: is it better to report any vulnerability that could cause catastrophic problems or to make the vulnerability information public in order to simultaneously compel the software vendor to address the problem while giving the vendor's customers a chance to prepare for potential exploitation? Software companies are facing this dilemma on a regular basis. There are dozens of websites, newsgroups, and e-mail lists dedicated to the task of sharing vulnerability information, whether condoned by the software company or not. The issue increases in severity as vulnerable software becomes ubiquitous across global networks. The public release of vulnerability information is often the first drop of the monsoon that is the malicious network worm. How this information is controlled and disseminated is critical to the stable operation of millions of computer systems and networks across the globe.Modern software with network capability is fundamentally complex and can span thousands of lines of source code for one small part of the package. Without proper testing and quality assurance, many bugs and errors slip through. Software development requires these iterations of coding and bug fixing to produce stable and polished final products. Larger and more complex software gives a greater chance for a bug to remain undiscovered. Yet, since major vulnerabilities have appeared in relatively smaller projects, proper code audit and testing are critical regardless of the size of a software package or the amount of source code required to produce it. If bugs or security vulnerabilities are not discovered and fixed by the software manufacturers, it is inevitable that they will be discovered by outside researchers.This breeds the ethical conundrum of what the researchers do with the information once it has been discovered. Foundational to disclosure, regardless of the ideology, is the notion of providing useful protective information to the most appropriate audience. Many suggest that disclosure is about doing the 'greatest good' for the greatest number of people, which is an obvious adherence to the ethical principle of Utilitarianism. There are numerous parties involved in the network security process such as software vendor, security researcher, system administrator, and even malicious attacker: all whose intentions reflect on the ethical principles behind their actions. (shrink)

Book reviewed in this article: Life Choices: Confronting the Life and Death Decisions Created by Modern Medicine. By Howard Levine. Hard Choices: Mixed Blessings of Modern Medical Technology. By B. D. Colen. The Sorcerer's Apprentice: Inside the Modem Hospital. By Sallie Tisdale. Playing God in the Nursery. By Jeff Lyon.

In this article we explore the underpinnings of what we view as a recent "backlash" in English law, a judicial reaction against considering children's and young people's expressions of their own feelings about treatment as their "true" wishes. We use this case law as a springboard to conceptual discussion, rooted in (a) empirical psychological work on child development and (b) three key philosophical ideas: rationality, autonomy and identity. Using these three concepts, we explore different understandings of our central theme, true (...) wishes. These different conceptual interpretations, we argue, help to elucidate important clinical questions in the area of children's informed consent to treatment. For example, how much should a child's own wishes count in making medical decisions? Does it make a difference if the child or young person is undergoing psychiatric treatment?—if in some sense her wishes are abnormal, not "true" expressions of what she really wants? If the child's wishes do not count, why not? If they do matter but count for less, how much less? We conclude by advocating functional tests of a young person's true wishes, applicable on a case-by-case basis, rather than a black-and-white distinction between "incompetent" children and "competent" adults. (shrink)

In this article we explore the underpinnings of what we view as a recent" backlash" in English law, a judicial reaction against considering children's and young people's expressions of their own feelings about treatment as their" true" wishes. We use this case law as a springboard to conceptual discussion, rooted in (a) empirical psychological work on child development and (b) three key philosophical ideas: rationality, autonomy and identity.

In lieu of an abstract, here is a brief excerpt of the content:Hume, Tillotson, and Dialogue XIIJeff JordanJeff JordanUniversity of DelawareFootnotes1. 'Natural religion' in the seventeenth and eighteenth centuries denoted knowledge of the divine which could be had via reason or instinct, independent of any purported special revelation.2. Of the two best works on Hume's philosophy of religion, J. C. A. Gaskin, Hume's Philosophy of Religion (Atlantic Highlands, New Jersey, 1988); and K. Yandell, Hume's "Inexplicable Mystery": His Views on Religion (...) (Philadelphia, 1990), only the first examines Hume's critique of the argument from prudence at all (see Hume's Philosophy of Religion, 194-203); but Gaskin's treatment of Hume's critique leaves untouched several important elements of the critique.3. B. Pascal, Pensées, ed. L. Lafuma, trans. J. Warrington (1670; reprint, London, 1960), 92-96.4. On Locke, see Essay Concerning Human Understanding (1690), bk. 2, chap. 21. On Leibniz, see Die Philosophischen Schriften, 3:621. On Craig, see Theologiae Christianae Principia Mathematica (1699), chap. 6. On Paley, see A View of the Evidences of Christianity (1795), pt. 3, chap. 8.5. Tillotson, "The Wisdom of Being Religious," Sermon 1 in Works of Tillotson (London, 1820), 1:317-89 (hereafter cited as W).6. I do not mean to suggest that Hume was aware only of the sermon "The Wisdom of Being Religious," but that Hume was aware of Tillotson's claims and arguments as found in several of his sermons. "The Wisdom of Being Religious" is important because (i) it is explicitly mentioned by Hume in his A Letter From A Gentleman to His Friend in Edinburgh (1745; reprint, Edinburgh, 1967), 23, so we know that Hume had read this sermon; (ii) it was one of the best known of Tillotson's sermons; and (iii) it contains all of the elements of Tillotson's argument from prudence.7. T. Birch, "Life of the Author," in Works of Tillotson, 1:xix-xx. See also L. G. Locke, Tillotson (Copenhagen, 1954).8. Tillotson may have been aware of the Port Royal Logic version of the wager through Locke with whom Tillotson was in correspondence. See Tillotson, 83.9. Tillotson's case for (1) is treated extensively in his sermon, "The Advantage of Religion to Societies," Sermon 3 in Works of Tillotson, 1:409-23.10. In the passage quoted (W 361-62), Tillotson claims that the atheist will naturally dread a superior being who can defeat one's plans and judge one's actions.11. See also "The Efficacy, Usefulness, and Reasonableness Of Divine Faith," Sermon 223 in Works of Tillotson, 9:258-79. The idea of a grand lie is first found in Plato; see Republic 3:389, 414, 5:459.12. "Pascalian Wagering," Canadian Journal of Philosophy 16, no. 3 (1986): 437-54.13. Though Tillotson mentions "odds" and "hazards," he does not incorporate probability values in his version of the wager. His wager is a decision under uncertainty and not a decision under risk: he does not, that is, calculate the expected utility of theistic belief. Pascal was the first to formulate the wager as a decision under risk where the probability-weighted averages of the utility values (the expected utility) determine the right choice.14. Of course, these principles were not stated explicitly until much later. See Ian Hacking, The Emergence of Probability (London, 1975).15. For an example of the many-gods objection, see M. Martin, Atheism: A Philosophical Justification (Philadelphia, 1990), 232-34. For a response to the many-gods objection see my "Pascal's Wager and the Many-Gods Objection," International Philosophical Quarterly 31, no. 3 (1991): 309-17.16. See David Hume, Dialogues Concerning Natural Religion, ed. N. Kemp Smith (1778; reprint, Indianapolis, 1947), 214, 218 (hereafter cited as "D").17. It should be noted that Philo's first point is interrupted by the second and is not completed until after the second is completed.18. I will assume that Philo speaks for Hume in this exchange with Cleanthes (D 219-27). Of the three points asserted by Philo in this exchange all three are asserted elsewhere by Hume. On the first point, see The Natural History of Religion (1757), secs. 9 and... (shrink)

Heidegger scholars consider the philosopher's recently published notebooks, including the issues of Heidegger's Nazism and anti-Semitism. For more than forty years, the philosopher Martin Heidegger logged ideas and opinions in a series of notebooks, known as the “Black Notebooks” after the black oilcloth booklets into which he first transcribed his thoughts. In 2014, the notebooks from 1931 to 1941 were published, sparking immediate controversy. It has long been acknowledged that Heidegger was an enthusiastic supporter of the Nazi Party in the (...) early 1930s. But the notebooks contain a number of anti-Semitic passages—often referring to the stereotype of “World-Jewry”—written even after Heidegger became disenchanted with the Nazis themselves. Reactions from the scholarly community have ranged from dismissal of the significance of these passages to claims that the anti-Semitism in them contaminates all of Heidegger's work. This volume offers the first collection of responses by Heidegger scholars to the publication of the notebooks. In essays commissioned especially for the book, the contributors offer a wide range of views, addressing not only the issues of anti-Semitism and Nazism but also the broader questions that the notebooks raise. Contributors Babette Babich, Andrew Bowie, Steven Crowell, Fred Dallmayr, Donatella Di Cesare, Michael Fagenblat, Ingo Farin, Gregory Fried, Jean Grondin, Karsten Harries, Laurence Paul Hemming, Jeff Malpas, Thomas Rohkrämer, Tracy B. Strong, Peter Trawny, Daniela Vallega-Neu, Friedrich-Wilhelm von Herrmann, Nancy A. Weston, Holger Zaborowski. (shrink)

Disgust is reasoned to operate in conjunction with the immune system to help protect the body from illness. However, less is known about the factors that impact the degree to which individuals invest in pathogen avoidance (disgust) versus pathogen management (prophylactic immunological activity). Here, we examine the role that one’s control over pathogen contact plays in resolving such investment trade-offs, predicting that (a) those from low control environments will invest less in pathogen-avoidance strategies and (b) investment in each of these (...) two strategies will occur in a compensatory fashion (i.e. they will be traded off with one other). Across four studies, we found support for these predictions, using a variety of manipulations and measures. By providing novel insights into how one’s control over pathogen exposure influences disgust sensitivity and immune system activity, the current research poses an important contribution to the literature on disgust, pathogen avoidance, and the immune system. (shrink)

We live in an age of “high tech” medicine which affects both health care recipients and physicians who are taught its many wonders and uses. It is easy in this atmosphere of specialization for clinicians, professors and medical students to become isolated and to ignore social issues which affect health care in its broadest sense.Individuals who are committed to the “common good” are the ones historically who have been effective change agents. It would be tragic simply to stand back and (...) allow the cynical and greedy to dominate any profession which deals with the poor, the uninsured and the homeless.It is imperative for physicians to take a broad view of today's problems in health care delivery systems, for they can have an enormous impact on the kind of world our children will inherit. It is essential for physicians to become involved in social concerns, and in improving health care delivery, at all levels in their practice.Given their power and prestige, it is crucial for physicians and aspiring physicians to have positive role models. Dr. Julius B. Richmond provides an admirable example of a physician who cares about his profession, his patients and his nation. Through his research, his public service and his teaching, Dr. Richmond has demonstrated the difference a single individual can make in improving the quality of life for all Americans. (shrink)